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MRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under Microgravity

ABSTRACT: DLD-1 and MOLT-4 cell lines were cultured in a Rotating cell culture system to simulate microgravity and mRNA expression profile was observed in comparison to Static controls Simulated microgravity affected the solid tumor cell line DLD-1 markedly which showed a higher percentage of dysregulated genes compared to the hematological tumor cell line, MOLT-4. Microgravity affects the cell cycle of DLD-1 cells and disturbs expression of cell cycle regulatory gene networks. Multiple microRNA host genes were dysregulated and significantly, mir-22, tumor suppressor microRNA, is highly upregulated in DLD-1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE69271 | GEO | 2017/02/07

SECONDARY ACCESSION(S): PRJNA285064

REPOSITORIES: GEO

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