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Expression data in histone-depleted cells [gene-level]

ABSTRACT: How chromatin controls transcription elongation and splicing is an open question. Here we determine the transcriptomic changes of cells partially depleted of core histones. For that we construct a cell line with Doxycycline-controlled levels of the histone regulatory protein SLBP (HCT-shSLBP). HCT-shSLBP is derived from the human colon cancer cell line HCT116. Exon level and gene level transcriptomic data of Doxycycline-treated cells is compared with that non-treated cells. The final goal is to determine how chromatin depletion affects transcription and splicing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE69307 | GEO | 2015/12/30

SECONDARY ACCESSION(S): PRJNA285114

REPOSITORIES: GEO

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