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Expression data from CD19-positive B-cells isolated from splenocytes from 8 week-old ingeneered mice from the indicated genotypes

ABSTRACT: The Ink4a/Arf tumor supressors play crucial roles in inhibiting cell cycle progression at the G1/S checkpoint. Activating mutations in the KrasG12D oncogene is one of the most frequent changes in human cancer, with resultant constitutive mitogenic signaling within the cell. We generated cohorts of CD19Cre, CD19Cre; KrasG12D, CD19Cre; Ink4a/ArfL/+, and CD19Cre; KrasG12D/+; Ink4a/ArfL/+ mice to evaluate the isolated or combined contributions of Ink/Arf loss and KrasG12D activation in B-cell development. In this data set we include the expression data obtained CD19-positive B-cells isolated from premalignant (8 weeks old ) mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE69367 | GEO | 2015/05/30

SECONDARY ACCESSION(S): PRJNA285321

REPOSITORIES: GEO

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