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Multi-dimensional histone modifications for coordinated regulation of gene expression under hypoxia [array]

ABSTRACT: Analysis of epigenetic changes at hypoxia at gene level. The hypothesis was that different types of methylation affect gene expression coordinately regulate specific induction or repression of hypoxia-responsive genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE69495 | GEO | 2017/08/17

SECONDARY ACCESSION(S): PRJNA285736

REPOSITORIES: GEO

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Multi-dimensional histone modifications for coordinated regulation of gene expression under hypoxia [ChIP-Seq]

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Multi-dimensional histone modifications for coordinated regulation of gene expression under hypoxia or clioquinol (CQ) treatment [gene expression]

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Multi-dimensional histone modifications for coordinated regulation of gene expression under hypoxia

Project description:This SuperSeries is composed of the SubSeries listed below.

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Multi-dimensional histone modifications for coordinated regulation of gene expression under hypoxia

Project description:Multi-dimensional histone modifications for coordinated regulation of gene expression under hypoxia

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Multi-dimensional histone methylations for coordinated regulation of gene expression under hypoxia.

Project description:Hypoxia increases both active and repressive histone methylation levels via decreased activity of histone demethylases. However, how such increases coordinately regulate induction or repression of hypoxia-responsive genes is largely unknown. Here, we profiled active and repressive histone tri-methylations (H3K4me3, H3K9me3, and H3K27me3) and analyzed gene expression profiles in human adipocyte-derived stem cells under hypoxia. We identified differentially expressed genes (DEGs) and differentially methylated genes (DMGs) by hypoxia and clustered the DEGs and DMGs into four major groups. We found that each group of DEGs was predominantly associated with alterations in only one type among the three histone tri-methylations. Moreover, the four groups of DEGs were associated with different TFs and localization patterns of their predominant types of H3K4me3, H3K9me3 and H3K27me3. Our results suggest that the association of altered gene expression with prominent single-type histone tri-methylations characterized by different localization patterns and with different sets of TFs contributes to regulation of particular sets of genes, which can serve as a model for coordinated epigenetic regulation of gene expression under hypoxia.

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Project description:Multi-dimensional histone modifications for coordinated regulation of gene expression under hypoxia or clioquinol (CQ) treatment.

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