Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC5714201 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nucleic acids research 20171101 20
Hypoxia increases both active and repressive histone methylation levels via decreased activity of histone demethylases. However, how such increases coordinately regulate induction or repression of hypoxia-responsive genes is largely unknown. Here, we profiled active and repressive histone tri-methylations (H3K4me3, H3K9me3, and H3K27me3) and analyzed gene expression profiles in human adipocyte-derived stem cells under hypoxia. We identified differentially expressed genes (DEGs) and differentiall ...[more]