Transcriptome analysis of CD4+ T cells reveals imprint of BACH2 and IFNγ regulation
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ABSTRACT: We used RNA sequencing to profile over 70 transcriptomes of CD4+ T cells, a cell type crucial for Coeliac Disease CD pathogenesis, in both stimulated and resting samples from individuals with CD and unaffected controls The data gave us the opportunity to (i) compare gene expression between cases and controls; (ii) specifically assess whether genes that have been genetically associated with the disease were being DE; (iii) and also look for known and novel aspects of pathogenesis in the transcriptome of this specific cellular compartment.
ORGANISM(S): Homo sapiens
PROVIDER: GSE69549 | GEO | 2015/08/17
SECONDARY ACCESSION(S): PRJNA285838
REPOSITORIES: GEO
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