Menin-MLL inhibitors block oncogenic transformation by MLL fusion proteins in a fusion partner independent manner
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ABSTRACT: Chromosomal rearrangements of the Mixed Lineage Leukemia (MLL) gene result in fusion proteins which retain the N-terminal portion of MLL fused with one of more than 70 different fusion partners. The high diversity of MLL fusion partners raises a question whether it is possible to develop a general therapeutic strategy to block the oncogenic activity of MLL fusion proteins in a fusion partner independent manner. We have demonstrated that blocking the menin-MLL interaction using small molecule inhibitor inhibits oncogenic activity of different MLL fusion proteins according to a mechanism that is independent on the fusion partner.
ORGANISM(S): Mus musculus
PROVIDER: GSE69740 | GEO | 2018/06/09
REPOSITORIES: GEO
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