Proteomics

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Protein Interactions of 7 MLL-fusion Proteins

ABSTRACT: MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL protein. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain poorly understood. We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins: MLL-AF1p, MLL-AF4, MLL-AF9, MLL-CBP, MLL-EEN, MLL-ENL and MLL-GAS7.

OTHER RELATED OMICS DATASETS IN: PRJNA433925

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell, Jurkat Cell

DISEASE(S): Acute Leukemia

SUBMITTER: Alexey Stukalov  

LAB HEAD: Florian Grebien

PROVIDER: PXD009338 | Pride | 2018-05-25

REPOSITORIES: Pride

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M391-C03-C1514-P4155-1.dat.gz Other
M391-C03-C1514-P4155-1.mgf.gz Mgf
M391-C03-C1514-P4155-1.pidres.xml.gz Xml
M391-C03-C1514-P4155-1.raw Raw
M391-C03-C1514-P4155-2.dat.gz Other
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Publications

MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain poorly understood. We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins. Functional investigation of 128 conserved MLL-fusion-interactors ide  ...[more]

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