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Hepatic gene expression in various different lots of chimeric mice with highly humanized liver

ABSTRACT: In addition to immunodeficiency, host mice for chimeric mice with highly humanized liver should have hepatic malfunction in order to allow higher replacement rate of human hepatocytes in the liver. Urokinase-type plasminogen activator (uPA) whole gene transfer is often employed to achieve hepatic malfunction in the host mice. We have established uPA cDNA transfer that is far stable, as compared with traditional whole uPA gene transfer. Hepatic gene expression was quite similar between whole uPA gene transfer and uPA cDNA transfer after transplantation of the same lot of human hepatocyte (BD195),, as compared with the variation of gene expression after transplantation of different lots of human hepatocytes to host mice with whole uPA gene transfer.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE69936 | GEO | 2015/06/17

SECONDARY ACCESSION(S): PRJNA287167

REPOSITORIES: GEO

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