Methylation profiling

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Methylation microarray studies highlight PDGFA expression as a factor in biliary atresia


ABSTRACT: Biliary atresia (BA) is a progressive fibro-inflammatory disorder that is the leading indication for liver transplantation in children. Although there is evidence implicating genetic, infectious, environmental, and inflammatory causes, the etiology of BA remains unknown. We have recently reported that cholangiocytes from BA patients showed decreased DNA methylation relative to disease- and non-disease controls, supporting a potential role for DNA hypomethylation in BA etiopathogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE69948 | GEO | 2015/06/18

SECONDARY ACCESSION(S): PRJNA287255

REPOSITORIES: GEO

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