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Function of deubiquitinase USP21 in mouse embryonic stem cell [RNA-Seq]

ABSTRACT: Ubiquitination-mediated protein degradation of key transcriptional factors is important to the self-renewal of embryonic stem (ES) cells. However, little is known about the deubiquitination in ES self-renewal and differentiation. Here, we report that deubiquitinase USP21 is an important positive regulator to keep ES cells under undifferentiation stasus by deubiquitination and stabilization of Nanog, a key transcriptional factor of ES cells. Loss of USP21 led to ES cells differentiation and defect in reprogramming.

ORGANISM(S): Mus musculus

PROVIDER: GSE69987 | GEO | 2016/10/05

SECONDARY ACCESSION(S): PRJNA287352

REPOSITORIES: GEO

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Function of deubiquitinase USP21 in mouse embryonic stem cell [ChIP-Seq]

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