Transcriptomics

Dataset Information

0

RNA sequencing analysis of DAF-16 target gene expression when math-33 function is genetically inactivated

ABSTRACT: In this study we have investigated the effect of loss of math-33 activity on DAF-16-mediated target gene regulation in C. elegans under conditions of reduced Insulin/IGF-1 signaling (IIS). Using whole nematode RNA sequencing experiments we found that the daf-2(e1370)-mediated induction and repression of DAF-16 target genes was decreased in daf-2(e1370); math-33(tm3561) mutant animals. Our data suggest that the downregulation of endogenous DAF-16 isoforms in the absence of a functional MATH-33 severely affects the global expression of DAF-16 targets when IIS activity is reduced. Therefore, MATH-33 is essential for DAF-16-mediated target gene activation and repression in the context of IIS.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE70117 | GEO | 2016/06/22

SECONDARY ACCESSION(S): PRJNA287674

REPOSITORIES: GEO

Json Xml

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

Transcriptomics RNA sequencing analysis of DAF-16 target gene expression when math-33 function is genetically inactivated
2016-06-22 | E-GEOD-70117 | biostudies-arrayexpress
Transcriptomics Endogenous DAF-16 genome-wide recruitment under low Insulin signalling condition in Caenorhabditis elegans
2016-03-01 | GSE67975 | GEO
Genomics Endogenous DAF-16 genome-wide recruitment under low Insulin signaling condition in Caenorhabditis elegans
2016-03-01 | GSE63865 | GEO
Transcriptomics Endogenous DAF-16 genome-wide recruitment under low Insulin signalling condition in Caenorhabditis elegans
2016-03-01 | E-GEOD-67975 | biostudies-arrayexpress
Genomics Endogenous DAF-16 genome-wide recruitment under low Insulin signaling condition in Caenorhabditis elegans
2016-03-01 | E-GEOD-63865 | biostudies-arrayexpress
Transcriptomics Transcription profiling of long-lived C.elegans daf-2 pathway mutants with wild type/short-lived mutants
2003-07-17 | E-MEXP-7 | biostudies-arrayexpress
Transcriptomics Analysis of nonsense-mediated mRNA decay in daf-2 mutants
2017-03-17 | GSE94077 | GEO
Transcriptomics Transcription profiling of C. elegans long luved daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) reveals insights into longevity
2007-07-05 | E-GEOD-1762 | biostudies-arrayexpress
Transcriptomics RNA-seq profile of two daf-2 (e1370);daf-12(m20) samples
2019-12-03 | GSE68669 | GEO
Transcriptomics C. elegans microarrays: daf-2(-) vs. daf-2(-) xbp-1(-)
2010-02-02 | E-GEOD-20148 | biostudies-arrayexpress