Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Arnab Mukhopadhyay
PROVIDER: E-GEOD-67975 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kumar Neeraj N Jain Vaibhav V Singh Anupama A Jagtap Urmila U Verma Sonia S Mukhopadhyay Arnab A
Oncotarget 20151201 39
Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the first recruitment profile of endogenous DAF-16 and show that the response is conserved. DAF-16 predominantly acts as a transcriptional activator and binding within the 0.5 kb promoter-proximal region results in maximum induction of downstream targets that code for proteins inv ...[more]