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The contained self-reactive peripheral T cell repertoire: size, diversity and cellular composition

ABSTRACT: To further characterize the self-reactive T cell population and determine if there are sub-compartments within the naïve T cell pool that are more likely to respond in the absence of Treg cell-mediated control, we focused on CD5. CD5 is a membrane protein that is associated with the TCR and its expression is correlated with higher signaling intensity, presumably due to higher TCR self-MHC/peptide affinity, during positive selection. FACS was used to purify three distinct populations of naïve CD4+ T cells from the bottom, middle and top 10 percent based on CD5 expression; CD5low, CD5int and CD5high.

ORGANISM(S): Mus musculus

PROVIDER: GSE70154 | GEO | 2015/08/04

SECONDARY ACCESSION(S): PRJNA287757

REPOSITORIES: GEO

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