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Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [RNA-Seq]

ABSTRACT: Mice were fed Se-deficient or Se-adequate diets for 6 weeks. Liver and lung tissue were harvested and processed for RNA-Seq, ribosome profiling, and microarray analysis. From these studies, we identified changes in mRNA levels and translation of selenoprotein genes and genes regulated by interferon-gamma. Cytokine profiles of serum indicated that interferon-gamma and IL-6 levels were increased in the Se-adequate mice relative to Se-deficient mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE70158 | GEO | 2015/08/06

SECONDARY ACCESSION(S): PRJNA287767

REPOSITORIES: GEO

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Dietary selenium levels affect selenoprotein expression and support the interferon-? and IL-6 immune response pathways in mice [microarray]

Project description:Mice were fed Se-deficient or Se-adequate diets for 6 weeks. Liver and lung tissue were harvested and processed for RNA-Seq, ribosome profiling, and microarray analysis. From these studies, we identified changes in mRNA levels and translation of selenoprotein genes and genes regulated by interferon-gamma. Cytokine profiles of serum indicated that interferon-gamma and IL-6 levels were increased in the Se-adequate mice relative to Se-deficient mice. Gene expression analysis of liver and lung tissue from mice fed Se-deficient or Se-adequate diets

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Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [RNA-Seq]

Project description:Mice were fed Se-deficient or Se-adequate diets for 6 weeks. Liver and lung tissue were harvested and processed for RNA-Seq, ribosome profiling, and microarray analysis. From these studies, we identified changes in mRNA levels and translation of selenoprotein genes and genes regulated by interferon-gamma. Cytokine profiles of serum indicated that interferon-gamma and IL-6 levels were increased in the Se-adequate mice relative to Se-deficient mice. RNA-Seq analysis of liver tissue from mice fed Se-deficient or Se-adequate diets

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Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [Ribosome Profiling]

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Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [microarray]

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The effects of dietary selenium on selenocysteine incorporation and selenoprotein expression

Project description:The goal of this study was to determine the effects of dietary selenium levels on translational control of selenoprotein synthesis in mouse liver.

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