Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional profiling of putative ABC Transporter gene orf19.4531 knockout in Candida albicans

ABSTRACT: Since, ABC transporters do perform various physiological roles.To get better insight about possible involvement of putative ABC transporter orf19.4531 in different functions transcriptional profiling have been peformed and compared between WT(SC5314) Candida albicans cells vs putative orf19.4531 knockout cells after 6hrs growth of culture.The assay as peformed in biological duplicate sample.

ORGANISM(S): Candida albicans

PROVIDER: GSE70340 | GEO | 2017/12/31

SECONDARY ACCESSION(S): PRJNA288333

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptional profiling of orf19.5100/MLT1 ABC transporter knockout in Candida albicans

2016-07-25 | GSE70341 | GEO

Transcriptional profiling of putative half ABC transporter gene orf19.3120 knockout cells in Candida albicans

Project description:Inventory of ABC transporters of Candida albicans shows presence of large no of ABC transporters in its genome.The large no of such protein presence suggested that these proteins may involve in various functions.To know involvement of PM ABC transporter orf19.3120 in different physiological roles transcriptional profiling have been peformed and compared between WT(SC5314) Candida albicans cells vs orf19.3120 knockout cells after 6hrs growth of culture.The assay as peformed in biological duplicate sample.

2021-12-31 | GSE70339 | GEO

Transcriptional profiling of orf19.5100/MLT1 ABC transporter knockout in Candida albicans

Project description:Recent reports have been suggested involvement of ABC transporters in various physiological roles.To get better insight about possible involvement of vacuolar ABC transporter MLT1/orf19.5100 in different physiological roles transcriptional profiling have been peformed and compared between WT(SC5314) Candida albicans cells vs putative orf19.5100 knockout cells after 6hrs growth of culture.The assay as peformed in biological duplicate sample. Agilent one-color experiment,Organism: Candida albicans ,Custom Agilent Candida albicans 8x15k Microarray Gene expression (AMADID: 026377) designed by Genotypic Technology Private Limited , Labeling kit: Agilent Quick-Amp labeling Kit (p/n5190-0442)

2016-07-25 | E-GEOD-70341 | biostudies-arrayexpress

The transcriptional regulator TFB-RF1 activates transcription of a putative ABC transporter in Pyrococcus furiosus

Project description:The transcriptional regulator TFB-RF1 activates transcription of a putative ABC transporter in Pyrococcus furiosus

| PRJEB25704 | ENA

ABC

Project description:ABC Assembly

| PRJNA809510 | ENA

The Plasmodium falciparum protein PfMRP1 functions as an influx ABC transporter

Project description:Adenosine triphosphate (ATP)-binding cassette (ABC) transporters play an important role in mediating solute or drug transport across cellular membranes. Although this class of transporters has been well characterized in diverse organisms little is known about the physiological roles in Plasmodium falciparum, the deadliest malaria parasite species. We studied the Plasmodium falciparum Multidrug Resistance-associated Protein 1 (PfMRP1; PF3D7_0112200), an ABC transporter localized to the parasite plasma membrane, generating genetic disrupted parasites. We demonstrate that parasites with disrupted pfmrp1 are resistant to folate analogs, methotrexate and aminopterin, with antimalarial activity. This phenotype occurs due to reduction in compound accumulation in the parasite cytoplasm. Phylogenetic analysis supports pfmrp1 being distantly related to ABC transporters in other eukaryotes, suggesting an unusual function. We propose that PfMRP1 can act as a solute importer, a function not previously observed in this organism.

2022-01-31 | GSE195649 | GEO

Adaptation of Cupriavidus metallidurans CH34 to toxic zinc concentrations involves an uncharacterized ABC-type transporter

Project description:Cupriavidus metallidurans CH34 is a well-studied metal-resistant β-proteobacterium and contains a battery of genes involved in the resistance and processing of numerous metals. Here, we performed a directed evolution experiment to obtain derivatives adapted to grow in the presence of zinc at concentrations above the minimal inhibitory concentration for the parental strain. Genetic characterization of one derivative, CH34ZnR, which was also more resistant to cadmium, revealed seven mutations, including inactivation of glpR coding for a DeoR-type transcriptional repressor by insertion of IS1088. The latter resulted in the constitutive expression of the neighboring ABC-type transporter. GlpR and the adjacent ABC transporter are highly similar to the glycerol operon regulator and ATP-driven glycerol importer of Rhizobium leguminosarum bv. viciae VF39, respectively. Deletion of glpR or the ABC transporter and complementation of CH34ZnR with the parental glpR gene further demonstrated that loss of GlpR function, with concomitant induction of the adjacent ABC transporter, is pivotal in the observed phenotype. Moreover, addition of glycerol, presumably by glycerol-mediated reduced GlpR activity, also promoted increased zinc and cadmium resistance. Thus, the ABC-type transporter is proposed to be a new adaptation route during exposure to toxic zinc concentrations.

2021-03-03 | GSE156826 | GEO

The expression profile of ABC transporter genes in post-treatment breast carcinomas

Project description:ATP-binding cassette (ABC) transporters contribute to development of resistance to anti-cancer drugs via ATP-dependent drug efflux. A major goal of our study was to investigate associations between expression of ABC transporters and outcome of breast carcinoma patients. ABCA5/6/8/9/10, ABCB1/5/11, ABCC6/9, ABCD2/4 and ABCG5/G8 were significantly downregulated and ABCA2/3/7/12, ABCB2/3/8/9/10, ABCC1/4/5/10/11/12, ABCD1/3, ABCE1, ABCF1/2/3 and ABCG1 upregulated in post-treatment tumors compared with non-neoplastic tissues. Significant associations of ABCC1 and ABCC8 levels in tumors with grade and expression of hormonal receptors were found. ABCA13 and ABCD2 levels significantly associated with the response to neoadjuvant chemotherapy in post-treatment patients.

2013-03-01 | GSE43807 | GEO

Candida albicans

Project description:Transcriptional profiling of putative ABC Transporter gene orf19.4531 knockout in Candida albicans

| PRJNA288333 | ENA

The expression profile of ABC transporter genes in post-treatment breast carcinomas

2013-03-01 | E-GEOD-43807 | biostudies-arrayexpress