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RNA-seq analyses of kdm5 mutant flies and wt flies under normal condition and oxidative stress

ABSTRACT: Comparing the transcriptome of wildtype and kdm5 mutant flies in normal conditions revealed a total of 4787 genes that were significantly downregulated and thus require KDM5 for their activation, and 3269 upregulated genes that are normally repressed by KDM5 (p<0.05, FDR <0.05). Because kdm5 mutants are sensitive to the oxidizer paraquat, we also carried out RNA-seq from wildtype and kdm5 mutant adults in oxidative stress conditions. Paraquat treatment of wildtype flies lead to the upregulation of 2481, and downregulation of 3103 genes

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE70590 | GEO | 2015/12/22

SECONDARY ACCESSION(S): PRJNA289117

REPOSITORIES: GEO

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RNA-seq analyses of kdm5 mutant flies and wt flies under normal condition and oxidative stress

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