Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Regulatory T cell modulation by CBP/EP300 bromodomain inhibition

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

OTHER RELATED OMICS DATASETS IN: PRJNA289193PRJNA289405

ORGANISM(S): Homo sapiens

PROVIDER: GSE70709 | GEO | 2016/04/08

SECONDARY ACCESSION(S): PRJNA289403

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.

Project description:Covalent modification of histones is a fundamental mechanism of regulated gene expression in eukaryotes, and interpretation of histone modifications is an essential feature of epigenetic control. Bromodomains are specialized binding modules that interact with acetylated histones, linking chromatin recognition to gene transcription. Because of their ability to function in a domain-specific fashion, selective disruption of bromodomain:acetylated histone interactions with chemical probes serves as a powerful means for understanding biological processes regulated by these chromatin adaptors. Here we describe the discovery and characterization of potent and selective small molecule inhibitors for the bromodomains of CREBBP/EP300 that engage their target in cellular assays. We use these tools to demonstrate a critical role for CREBBP/EP300 bromodomains in regulatory T cell biology. Because regulatory T cell recruitment to tumors is a major mechanism of immune evasion by cancer cells, our data highlight the importance of CREBBP/EP300 bromodomain inhibition as a novel, small molecule-based approach for cancer immunotherapy.

| S-EPMC4933219 | biostudies-literature

Bromodomain inhibition of the co-activators CBP/EP300 facilitates reprogramming

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-02-14 | GSE118220 | GEO

Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-01-05 | E-GEOD-71911 | biostudies-arrayexpress

Regulatory T cell modulation by CBP/EP300 bromodomain inhibition [array]

Project description:Genome-wide gene expression changes in response to CBP inhibitor treatment in Treg cells using microarray. Expression profiling by microarray of Treg cells treated with DMSO or CBP inhibitor, and Th0 cells

2016-07-06 | E-GEOD-66596 | biostudies-arrayexpress

Regulatory T cell modulation by CBP/EP300 bromodomain inhibition [RNA-seq]

Project description:Genome-wide gene expression changes in response to CBP inhibitor treatment in Treg cells using RNA sequencing (RNA-seq). Expression profiling by RNA-seq of Treg cells treated with DMSO or CBP inhibitor

2016-04-06 | E-GEOD-70620 | biostudies-arrayexpress

Regulatory T cell modulation by CBP/EP300 bromodomain inhibition [ChIP-seq]

Project description:Genome-wide chromatin H3K27ac, H3K18ac and H3K4me3 occupancy changes in response to CBP inhibitor treatment in Treg cells using ChIP sequencing (ChIP-seq). Expression profiling by ChIP-seq of Treg cells treated with DMSO or CBP inhibitor

2016-04-06 | E-GEOD-70708 | biostudies-arrayexpress

Regulatory T cell modulation by CBP/EP300 bromodomain inhibition [array]

Project description:Genome-wide gene expression changes in response to CBP inhibitor treatment in Treg cells using microarray.

2016-07-06 | GSE66596 | GEO

Activity of EP300/CBP bromodomain inhibitor CCS1477 across diverse hematologic malignancies

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-11-28 | GSE207357 | GEO

Epigenetic regulation of tumor-associated myeloid cell activity by CBP/EP300 bromodomain

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-05-31 | GSE124333 | GEO

Regulatory T cell modulation by CBP/EP300 bromodomain inhibition [ChIP-seq]

Project description:Genome-wide chromatin H3K27ac, H3K18ac and H3K4me3 occupancy changes in response to CBP inhibitor treatment in Treg cells using ChIP sequencing (ChIP-seq).

2016-04-06 | GSE70708 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data