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Lactobacilli modulate epithelial cytoprotection through the Nrf2 pathway

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Drosophila melanogaster

PROVIDER: GSE70715 | GEO | 2015/09/01

SECONDARY ACCESSION(S): PRJNA294320

REPOSITORIES: GEO

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Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway.

Project description:An optimal gut microbiota influences many beneficial processes in the metazoan host. However, the molecular mechanisms that mediate and function in symbiont-induced host responses have not yet been fully characterized. Here, we report that cellular ROS enzymatically generated in response to contact with lactobacilli in both mice and Drosophila has salutary effects against exogenous insults to the intestinal epithelium via the activation of Nrf2 responsive cytoprotective genes. These data show that the xenobiotic-inducible Nrf2 pathway participates as a signaling conduit between the prokaryotic symbiont and the eukaryotic host. Indeed, our data imply that the capacity of lactobacilli to induce redox signaling in epithelial cells is a highly conserved hormetic adaptation to impel cellular conditioning to exogenous biotic stimuli. These data also highlight the role the microbiota plays in eukaryotic cytoprotective pathways and may have significant implications in the characterization of a eubiotic microbiota.

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Lactobacilli modulate epithelial cytoprotection through the Nrf2 pathway [RNA-Seq]

Project description:We report that cellular ROS enzymatically generated in response to contact with lactobacilli in both mice and Drosophila has salutary effects against exogenous insults to the intestinal epithelium via the activation of Nrf2 responsive cytoprotective genes. RNA was isolated from the colons of untreated, PBS, E. coli, and LGG innoculated germ free mice and RNA-seq performed to identify the gene expression in response to each condition

2015-09-01 | E-GEOD-72552 | biostudies-arrayexpress

Lactobacilli modulate epithelial cytoprotection through the Nrf2 pathway [Microarray]

2015-09-01 | GSE72553 | GEO

Lactobacilli modulate epithelial cytoprotection through the Nrf2 pathway [RNA-Seq]

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