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Gene expression profiling in MCF7 cell lines under hypoxia and reoxygenation

ABSTRACT: Purpose: Study hypoxia and reoxygenation induced changes in genome-wide gene expression Methods: Using the MCF7 breast epithelial adenocarcinoma cell line as a model, we studied epigenomic reprogramming as a function of fluctuating oxygen tension. To this end, we performed a transcriptomics analysis in MCF7 cells subjected to changes in oxygenation (i.e. acute hypoxia, chronic hypoxia, reoxygenation). Results: Global downregulation upon hypoxia; partial restore on reoxygenation. Conclusions: Our data show that oxygen availability dynamically regulates gene transcription.

ORGANISM(S): Homo sapiens

PROVIDER: GSE70805 | GEO | 2016/11/01

SECONDARY ACCESSION(S): PRJNA289570

REPOSITORIES: GEO

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