Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data (micro-array, frozen tumors) from various sarcomas

ABSTRACT: We validated the technological and material transfers of the CINSARC signature.

ORGANISM(S): Homo sapiens

PROVIDER: GSE71118 | GEO | 2016/03/03

SECONDARY ACCESSION(S): PRJNA290394

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Expression data (micro-array, frozen tumors) from various sarcomas

Project description:We validated the technological and material transfers of the CINSARC signature. We performed both microarray and RNA-seq analysis and compared prognostic values based on the CINSARC classification. We measure significant metastasis-free survivals with both approaches. Additionally, depending on RNA degradation, transcriptomic analysis from FFPE blocks show similar CINSARC classification.

2016-03-03 | E-GEOD-71118 | biostudies-arrayexpress

RNA-seq performed on sarcomas to identify various alterations

Project description:We validated the technological and material transfers of the CINSARC signature.

2016-03-03 | GSE71119 | GEO

RNA-seq performed on sarcomas to identify various alterations

2016-03-03 | E-GEOD-71119 | biostudies-arrayexpress

RNA-seq performed on FFPE sarcoma blocks

Project description:We validated the technological and material transfers of the CINSARC signature.

2016-03-03 | GSE71120 | GEO

RNA-seq performed on FFPE sarcoma blocks

2016-03-03 | E-GEOD-71120 | biostudies-arrayexpress

Expression data (micro-array and RNA-seq, frozen tumors and FFPE blocks) from various sarcomas

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-03-03 | GSE71121 | GEO

Expression data (micro-array and RNA-seq, frozen tumors and FFPE blocks) from various sarcomas

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-03-03 | E-GEOD-71121 | biostudies-arrayexpress

Expression data (micro-array and RNA-seq, frozen tumors and FFPE blocks) from various sarcomas

Project description:Expression data (micro-array and RNA-seq, frozen tumors and FFPE blocks) from various sarcomas

| PRJNA290393 | ENA

Expression data from 58 Synovial Sarcomas

Project description:Background: Synovial sarcoma (SS) occur in children as well as in adults, although metastatic events are much more common in the latter. Whereas the importance of the t(X;18) translocation in SS oncogenesis is well established, the genetic basis of SS metastasis is still poorly understood. We recently reported expression (CINSARC) and genomic (GI) prognostic signatures related to chromosome integrity in sarcomas and gastrointestinal stromal tumors (GISTs). Here we investigate whether these signatures can also predict outcomes in SS. Methods: One hundred primary untreated SS were selected for expression and genomic profiling in a training/validation approach. Results: CINSARC and GI have strong, independent and validated prognostic values (p<0.0001). Comparing expression profiles of tumors with or without metastasis, 14 genes common with the CINSARC signature were identified and the two top-ranked genes, KIF14 and CDCA2, were validated as prognostic markers in an independent cohort. Comparing genomic profiles of adult vs. pediatric SS, we show that metastasis is associated with genome complexity in both situations and that the adult genome is more frequently rearranged. Accordingly, pediatric patients with an even genomic profile do not develop metastasis. Conclusions: Metastasis development in SS is strongly associated with chromosome complexity, and CINSARC and GI are validated independent prognostic factors. The differences in metastasis frequency between adults and children are associated with genome instability, which is much more frequent in adults. GI is potentially the best overall biomarker, and clearly the most clinically relevant, considering that genome profiling from formalin fixed samples is already used in pathology.

2014-08-09 | GSE40021 | GEO

Expression data from 34 Synovial Sarcomas

2014-08-09 | GSE40018 | GEO