Expression data from Jurkat cells treated with SB225002 for 6h and 9h.

ABSTRACT: In our efforts to evaluate the function of the IL-8 receptor CXCR2 in Acute Lymphoblastic Leukemia (ALL) cells, we made use of SB225002 (N-(2-hydroxy-4-nitrophenyl)-N’-(2-bromophenyl)urea), a drug initially described as a CXCR2 antagonist. Although the CXCR2 receptor was found to be non-functional in ALL, B- and T-ALL cell lines were sensitive to SB225002. We used microarray analysis to identify a transcriptional profile of genes that mediate SB225002's effects in acute lymphoblastic leukemia cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE71212 | GEO | 2015/07/23

SECONDARY ACCESSION(S): PRJNA290610

REPOSITORIES: GEO