Transcriptomics

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Maternal Nurtritional Programming in the Ovine Mammary Gland


ABSTRACT: Developmental programming is the concept that environmental factors, particularly during foetal life, can alter development, metabolism and physiology of an organism and this can have consequences later in life. There is growing interest in developmental programming in livestock species, particularly effects of maternal pregnancy nutrition, which is easy to manipulate. Recent research, using a sheep model, has shown that milk production in ewe offspring may be susceptible to maternal nutritional programming, such that over nutrition (ad libitum) of the pregnant dam, compared with maintenance nutrition, may impair their first lactation performance and result in the weaning of lighter lambs. RNA-seq was performed to identify gene expression differences as a result of maternal nutrition in ewe offspring during their first parity. Samples were collected in late pregnancy and during lactation, allowing us to examine gene expression changes during maturation of the ovine mammary gland.

ORGANISM(S): Ovis aries

PROVIDER: GSE71424 | GEO | 2015/07/29

SECONDARY ACCESSION(S): PRJNA291187

REPOSITORIES: GEO

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