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Gene expression of rat cerebellum in a new animal model of hepatic encephalopathy (HE)

ABSTRACT: Identify differentially expressed genes related to the neurodegenerative process in a new animal model of hepatic encephalopathy (HE). The animal model consists on the simulation of several bouts of HE in PCA rats, being the precipitant factors of the episodes ammonia (NH3) and/or lipopolisaccharide (LPS) or saline.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE71425 | GEO | 2015/07/29

SECONDARY ACCESSION(S): PRJNA291186

REPOSITORIES: GEO

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Gene expression of rat cerebellum in a new animal model of hepatic encephalopathy (HE)

Project description:Identify differentially expressed genes related to the neurodegenerative process in a new animal model of hepatic encephalopathy (HE). The animal model consists on the simulation of several bouts of HE in PCA rats, being the precipitant factors of the episodes ammonia (NH3) and/or lipopolisaccharide (LPS) or saline. Regular administration (one every two weeks up to 10 infussion) of NH3 (20 μl/min along 3h) and/or LPS (5mg/kg) or in PCA rats. Sham rats were used as a surgery control.

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