Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata

ABSTRACT: In order to understanding the transcriptome responses of the amebocyte-producing organ (APO) of the snails Biomphalaria glabrata after exposure to pathogen associated molecular patterns (PAMPs), we investigated transcriptomic responses of the APO dissected from the snails at 24 hours post-injection with bacterial pathogen-associated molecular patterns (PAMPs). Three PAMPs that include lipopolysaccharide (LPS), peptidoglycan, and fucoidan that may mimic fucosyl-rich glycan PAMPs on sporocysts of Schistosoma mansoni, were tested. Based upon the number of genes differentially expressed, LPS exhibited the strongest activity, relative to saline-injected controls. A concurrent activation of genes involved in cell proliferation, immune response and detoxification metabolism was observed.

ORGANISM(S): Biomphalaria glabrata

PROVIDER: GSE71607 | GEO | 2015/08/01

SECONDARY ACCESSION(S): PRJNA291611

REPOSITORIES: GEO