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Altered Gene Expression in the Schistosome- Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide

ABSTRACT: In order to understanding the mechanisms of action of niclosamide, the active ingredient in the molluscicides, we used a Biomphalaria glabrata oligonucleotide microarray to investigate the effect of three sublethal exposures to niclosamide on the transcriptional responses of the snail B. glabrata relative to untreated snails. In addition to inducing biotransformation activity and inducing stress responses, niclosamide exposures also resulted in altered function of vesicle trafficking and may affect the snail’s oxygen binding capacity.

ORGANISM(S): Biomphalaria glabrata

PROVIDER: GSE71223 | GEO | 2015/07/23

SECONDARY ACCESSION(S): PRJNA290628

REPOSITORIES: GEO

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