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Transgenic overexpression of Pla2g10 display alopecia and epidermal hyperplasia

ABSTRACT: Microarray gene profiling of skin from PLA2G10-Tg mice in comparison with that from control mice yielded data for explaining the overall tendency of Tg skin to show hair follicle distortion and epidermal hyperplasia associated with hyperkeratosis in the absence of inflammation

ORGANISM(S): Mus musculus

PROVIDER: GSE71827 | GEO | 2015/08/08

SECONDARY ACCESSION(S): PRJNA292159

REPOSITORIES: GEO

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Transgenic overexpression of Pla2g10 display alopecia and epidermal hyperplasia

Project description:Microarray gene profiling of skin from PLA2G10-Tg mice in comparison with that from control mice yielded data for explaining the overall tendency of Tg skin to show hair follicle distortion and epidermal hyperplasia associated with hyperkeratosis in the absence of inflammation Pla2g10-Tg/+ mice and littermate controls (C57BL/6 background); 25-day old; skin; pooled from 4 mice for each genotype.

2015-08-08 | E-GEOD-71827 | biostudies-arrayexpress

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Project description:Our goal was to develop a transcriptomic description of affected alopecic scalp skin from patients with alopecia areata. 5 biological replicates of skin samples from 5 separate AA patients compared with 5 similar scalp samples from healthy control patients

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