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Repeated monthly epicutaneous challenges with diphenylcyclopropenone (DPCP).

ABSTRACT: The level of reactivity in pre-sensitized individuals following repeated epicutaneous challenges with diphenylcyclopropenone (DPCP) remains unknown. We studied the kinetics and time-course of the developing reactivity to this potent contact sensitizer using genome-wide gene expression data

ORGANISM(S): Homo sapiens

PROVIDER: GSE71996 | GEO | 2016/01/01

SECONDARY ACCESSION(S): PRJNA292693

REPOSITORIES: GEO

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Repeated monthly epicutaneous challenges with diphenylcyclopropenone (DPCP).

Project description:The level of reactivity in pre-sensitized individuals following repeated epicutaneous challenges with diphenylcyclopropenone (DPCP) remains unknown. We studied the kinetics and time-course of the developing reactivity to this potent contact sensitizer using genome-wide gene expression data Ten healthy human volunteers were sensitized to DPCP. Five or six elicitation challenges were performed and punch biopsies were selected from vehicle control and challenge sites for RNA extraction and hybridization on Affymetrix microarrays.

2016-07-03 | E-GEOD-71996 | biostudies-arrayexpress

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Early Activation of Th2 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions

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Skin inflammation exacerbates food allergy symptoms in epicutaneously sensitized mice

Project description:Cutaneous exposure to food antigen through impaired skin barrier has been shown to induce epicutaneous sensitization, and thereby cause IgE-mediated food allergy. We examined whether skin barrier impairment deteriorated food allergy symptoms in epicutaneously sensitized mice. To clarify the association between skin inflammation and food allergy symptoms, we analyzed gene expression at skin lesions using a GeneChip.

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human serum: Control vs. patients with repeated implantation failure

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Multiple Low-dose Challenges in a Rhesus Macaque AIDS Vaccine Trial Result in an Evolving Host Response that affects Protective Outcome

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Homo sapiens

Project description:Blood DNA methylation biomarkers predict clinical reactivity in food-sensitized infants

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