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Repeated monthly epicutaneous challenges with diphenylcyclopropenone (DPCP).

ABSTRACT: The level of reactivity in pre-sensitized individuals following repeated epicutaneous challenges with diphenylcyclopropenone (DPCP) remains unknown. We studied the kinetics and time-course of the developing reactivity to this potent contact sensitizer using genome-wide gene expression data

ORGANISM(S): Homo sapiens

PROVIDER: GSE71996 | GEO | 2016/01/01

SECONDARY ACCESSION(S): PRJNA292693

REPOSITORIES: GEO

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Repeated monthly epicutaneous challenges with diphenylcyclopropenone (DPCP).

Project description:The level of reactivity in pre-sensitized individuals following repeated epicutaneous challenges with diphenylcyclopropenone (DPCP) remains unknown. We studied the kinetics and time-course of the developing reactivity to this potent contact sensitizer using genome-wide gene expression data Ten healthy human volunteers were sensitized to DPCP. Five or six elicitation challenges were performed and punch biopsies were selected from vehicle control and challenge sites for RNA extraction and hybridization on Affymetrix microarrays.

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