Ontology highlight
ABSTRACT:
ORGANISM(S): Macaca mulatta
SUBMITTER: Hildegund Ertl
PROVIDER: E-MTAB-1130 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kurupati Raj R Tuyishime Steve S Kossenkov Andrew V AV Sazanovich Marina M Haut Larissa H LH Lasaro Marcio O MO Ratcliffe Sarah J SJ Bosinger Steven E SE Carnathan Diane G DG Lewis Mark M Showe Louise C LC Silvestri Guido G Ertl Hildegund C J HC
Journal of leukocyte biology 20121227 3
In this study, we compared the immunogenicity and protection from repeated low-dose intrarectal SIVmac251 challenge in two groups of vaccinated RMs. Animals were immunized with live SIVmac239, which had been attenuated by a deletion of the nef sequence, or they were vaccinated twice with an E1-deleted AdHu5, expressing SIVmac239gag. The vaccinated animals and a cohort of unvaccinated control animals were then challenged 10 times in weekly intervals with low doses of SIVmac251 given rectally. Our ...[more]