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NOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence [N1ICD]

ABSTRACT: ER:RAS-G12V expressing IMR90 cells were transduced with N1ICD-containing or control vectors before treatment with either 100nM 4-OHT or vehicle for 6 days leading to Notch-induced senescence (NIS), RAS-induced senescence (RIS) or combined Notch and Ras-induced senescence (RNIS).

ORGANISM(S): Homo sapiens

PROVIDER: GSE72404 | GEO | 2016/06/22

SECONDARY ACCESSION(S): PRJNA293982

REPOSITORIES: GEO

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