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NOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence [CSM]

ABSTRACT: ER:RAS-G12V expressing IMR90 cells were treated with either 100nM 4-OHT for 6 days or 100uM Etoposide for 2 days, followed by further culture for 5 days, leading to RAS-induced senescence (RIS) and DNA-damage induced senescence (DDIS) respectively.

ORGANISM(S): Homo sapiens

PROVIDER: GSE72407 | GEO | 2016/06/22

SECONDARY ACCESSION(S): PRJNA293984

REPOSITORIES: GEO

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NOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence [N1ICD]

Project description:ER:RAS-G12V expressing IMR90 cells were transduced with N1ICD-containing or control vectors before treatment with either 100nM 4-OHT or vehicle for 6 days leading to Notch-induced senescence (NIS), RAS-induced senescence (RIS) or combined Notch and Ras-induced senescence (RNIS).

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Project description:We describe the accessible chormatin landscape in RAS-induced (RIS) and NOTCH induced senescence (NIS) using ATAC-seq. By expressing active NOTCH (N1ICD) in the context of RIS, we find that N1ICD antagonizes the formation of accessible regions in RIS. By performing co-cultures, we demonstrate that cells expressing a NOTCH1 ligand, JAGGED1, can antagonize the formation of RIS specific accessible regions.

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Gene expression profiles of Ras mutants.

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