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The Ro60 Autoantigen Binds Endogenous Retroelements and Regulates Inflammatory Gene Expression

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

OTHER RELATED OMICS DATASETS IN: PRJNA294173PRJNA294187PRJNA294172PRJNA294174PRJNA294175

ORGANISM(S): Homo sapiens

PROVIDER: GSE72420 | GEO | 2015/09/16

SECONDARY ACCESSION(S): PRJNA294172

REPOSITORIES: GEO

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The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.

Project description:Autoantibodies target the RNA binding protein Ro60 in systemic lupus erythematosus (SLE) and Sjögren's syndrome. However, it is unclear whether Ro60 and its associated RNAs contribute to disease pathogenesis. We catalogued the Ro60-associated RNAs in human cell lines and found that among other RNAs, Ro60 bound an RNA motif derived from endogenous Alu retroelements. Alu transcripts were induced by type I interferon and stimulated proinflammatory cytokine secretion by human peripheral blood cells. Ro60 deletion resulted in enhanced expression of Alu RNAs and interferon-regulated genes. Anti-Ro60-positive SLE immune complexes contained Alu RNAs, and Alu transcripts were up-regulated in SLE whole blood samples relative to controls. These findings establish a link among the lupus autoantigen Ro60, Alu retroelements, and type I interferon.

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