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Dendritic Cells Compare the Similarity of Endogenous and Exogenous Antigens

ABSTRACT: Here we demonstrate by the use of extensive controls and stringent statistical analysis that dendritic cells differentially regulate hundreds of different genes based upon sequence similarity of endogenously- and exogenously-loaded antigens and in a T-cell independent fashion. When endogenously and exogenously-derived antigens are identical, dendritic cells upregulate many different components of the Th-1 response, favoring the priming of CD8+ effectors and promulgating cellular immunity. Keywords: Loading methodology comparison

ORGANISM(S): Homo sapiens

PROVIDER: GSE7247 | GEO | 2007/04/12

SECONDARY ACCESSION(S): PRJNA97997

REPOSITORIES: GEO

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