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Effects of ursolic acid and tomatidine on skeletal muscle mRNA expression in aged mice.

ABSTRACT: For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy.

ORGANISM(S): Mus musculus

PROVIDER: GSE72651 | GEO | 2015/09/03

SECONDARY ACCESSION(S): PRJNA294596

REPOSITORIES: GEO

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Effects of ursolic acid and tomatidine on skeletal muscle mRNA expression in aged mice.

Project description:For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. Weight-matched cohorts of 22-month-old male C57BL/6 mice were provided ad libitum access to standard chow (control) or standard chow supplemented with 0.27% ursolic acid (UA) or 0.05% tomatidine (TM) for 2 months. After the 2 month treatment period, quadriceps femoris muscles were harvested. mRNA levels in muscles harvested from ursolic acid or tomatidine fed mice were normalized to levels in muscles fed control diet.

2015-09-03 | E-GEOD-72651 | biostudies-arrayexpress

Effect of muscle-specific ATF4 gene knockout (ATF4 mKO) on skeletal muscle mRNA levels in aged mice.

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Effect of ATF4 gene knockout on skeletal muscle mRNA levels in fasted mice.

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Effect of ATF4 overexpression on mRNA levels in differentiated C2C12 myotubes.

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