To identify genes responsive to treatment with the HIF2a inhibitor PT2399
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ABSTRACT: HIF2a function is both necessary and sufficient for the growth of VHL-null clear cell Renal Cell Carcinoma (ccRCC). Targeting HIF2a function can therefore be a promising therapeutic strategy. We used microarray analysis to characterize a novel pharmacological inhibitor of HIF2a named PT2399. By comparing genes that are responsive to PT2399 in parental cells vs cells lacking HIF2a, by virtue of CRISPR-mediated genetic editing, we characterized gene signatures that are regulated by PT2399 in a HIF2a dependent manner.
ORGANISM(S): Homo sapiens
PROVIDER: GSE72959 | GEO | 2016/01/01
SECONDARY ACCESSION(S): PRJNA295413
REPOSITORIES: GEO
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