Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Evangelia Papachristou
LAB HEAD: Sakari Vanharanta
PROVIDER: PXD029522 | Pride | 2022-03-14
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Q_Exactive_HIF2A_01.msf | Msf | |||
Q_Exactive_HIF2A_01.raw | Raw | |||
Q_Exactive_HIF2A_02.msf | Msf | |||
Q_Exactive_HIF2A_02.raw | Raw | |||
Q_Exactive_HIF2A_03.msf | Msf |
Items per page: 1 - 5 of 25 |
Nature 20220608 7916
Large-scale human genetic data<sup>1-3</sup> have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analyses of patient samples, we demonstrate that the lineage transcription factor paired box 8 (PAX8) is required for oncogenic signalling by two common genetic alterations that cause clear cell renal cell carcinoma (ccRCC) in humans: the germline variant rs7948643 at 11q13.3 and ...[more]