Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Control males

ABSTRACT: gene expression profiles of lymphoblastoid cells from control males without autism Keywords: control males

ORGANISM(S): Homo sapiens

PROVIDER: GSE7317 | GEO | 2007/06/01

SECONDARY ACCESSION(S): PRJNA104063

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcription profiling of human lymphoblastoid cells from control males without autism

Project description:gene expression profiles of lymphoblastoid cells from control males without autism Experiment Overall Design: Cy5; each control male Experiment Overall Design: Cy3; pool of 14 unrelated individuals.

2008-06-15 | E-GEOD-7317 | biostudies-arrayexpress

Transcription profiling of human lymphoblastoid cells from control males without autism

Project description:gene expression profiles of lymphoblastoid cells from individuals with autism and full mutation of FMR1 Experiment Overall Design: Cy5; each individual with autism and FMR1FM Experiment Overall Design: Cy3; pool of 14 unrelated individuals.

2008-06-15 | E-GEOD-7316 | biostudies-arrayexpress

autism with FMR1FM

Project description:gene expression profiles of lymphoblastoid cells from individuals with autism and full mutation of FMR1 Keywords: autism with FMR1-FM

2007-06-01 | GSE7316 | GEO

autism with dup(15q)

Project description:gene expression profiles of lymphoblastoid cells from individuals with autism and duplication of 15q11-13 Keywords: autism with dup(15q)

2007-06-01 | GSE7315 | GEO

Epigenome analysis of control and neurodevelopmental disorder lymphoblastoid cell lines

Project description:Genome wide DNA methylation profiling of control and neurodevelopmental disorder lymphoblastoid cell lines (LCL). The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in LCLs. Samples included 19 control, 18 Rett syndrome, 17 autism and 6 generalized epilepsy LCL samples. Six technical replicates were also included in the analysis.

2012-12-01 | GSE34099 | GEO

Transcription profiling of human lymphoblastoid cells from individuals with autism and duplication of 15q11-13autism with dup(15q)

Project description:gene expression profiles of lymphoblastoid cells from individuals with autism and duplication of 15q11-13 Experiment Overall Design: Cy5; each male with autism and dup(15q) Experiment Overall Design: Cy3; pool of 14 unrelated individuals.

2008-06-15 | E-GEOD-7315 | biostudies-arrayexpress

Epigenome analysis of control and neurodevelopmental disorder lymphoblastoid cell lines

2012-12-01 | E-GEOD-34099 | biostudies-arrayexpress

adult males vs reference

Project description:wild type adult males vs mixed stage reference Keywords: other

2003-12-31 | GSE723 | GEO

Gene expression profiling of lymphoblastoid cell lines from autistic and nonaffected sib pairs

Project description:Despite the identification of numerous autism susceptibility genes, the pathobiology of autism remains unknown. The present “case-control” study takes a global approach to understanding the molecular basis of autism spectrum disorders based upon large-scale gene expression profiling. DNA microarray analyses were conducted on lymphoblastoid cell lines from over 20 sib pairs in which one sibling had a diagnosis of autism and the other was not affected in order to identify biochemical and signaling pathways which are differentially regulated in cells from autistic and nonautistic siblings. Bioinformatics and gene ontological analyses of the data implicate genes which are involved in nervous system development, inflammation, and cytoskeletal organization, in addition to genes which may be relevant to gastrointestinal or other physiological symptoms often associated with autism. Moreover, the data further suggests that these processes may be modulated by cholesterol/steroid metabolism, especially at the level of androgenic hormones. Elevation of male hormones, in turn, has been suggested as a possible factor influencing susceptibility to autism, which affects ~4 times as many males as females. Metabolic profiling of steroid hormones in lymphoblastoid cell lines from several pairs of siblings reveals higher levels of testosterone in the autistic sibling, which is consistent with the increased expression of two genes involved in the steroidogenesis pathway. Global gene expression profiling of cultured cells from ASD probands thus serves as a window to underlying metabolic and signaling deficits that may be relevant to the pathobiology of autism.

2009-07-27 | GSE15451 | GEO

no germline males vs reference

Project description:no germline glp-4 adult males vs mixed stage reference Keywords: other

2003-12-31 | GSE724 | GEO