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Rgg-dependent transcriptional regulation in SF370 Streptococcus pyogenes strain

ABSTRACT: Rgg-dependent transcriptional regulation in SF370 Streptococcus pyogenes strain was analyzed during post-exponential phase of growth Keywords: rgg mutant

ORGANISM(S): Streptococcus pyogenes

PROVIDER: GSE7335 | GEO | 2008/02/01

SECONDARY ACCESSION(S): PRJNA98061

REPOSITORIES: GEO

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Rgg-dependent transcriptional regulation in SF370 Streptococcus pyogenes strain

Project description:Rgg-dependent transcriptional regulation in SF370 Streptococcus pyogenes strain was analyzed during post-exponential phase of growth Keywords: rgg mutant Microarray analysis was performed using RNA samples isolated from both wild-type SF370 and SF370 rgg mutant strains during post-exponential phase of growth

2010-05-26 | E-GEOD-7335 | biostudies-arrayexpress

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Project description:Rgg-dependent transcriptional regulation in Streptococcus pyogenes strains MGAS5005 and CS101 was analyzed during post-exponential phase of growth Keywords: strain comparion, post-exponential growth, rgg mutant Microarray analysis was performed using RNA samples isolated from wild-type MGAS5005 and CS101 strains as well as their rgg mutant strains during post-exponential phase of growth

2010-05-26 | E-GEOD-7341 | biostudies-arrayexpress

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Project description:Streptococcus pyogenes growth-phase dependent and Rgg-dependent transcription was analyzed Keywords: transcriptional regulation

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Expression analysis of Streptococcus pyogenes isolate SF370 and its rgg2 mutant

Project description:Differences in gene expression between the wild-typ SF370 and its rgg2 mutant was identified with samples collected from mid-exponential and post-exponential phases of growth

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Project description:Rgg-dependent transcriptional regulation in SF370 Streptococcus pyogenes strain

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Proteome driven re-evaluation and functional annotation of Streptococcus pyogenes SF370 genome.

Project description:Shotgun proteomic analysis for re-evaluation of genome S. pyogenes SF370, by using RP-HPLC ion trap MS/MS with six-frame database.

2011-11-18 | PRD000562 | Pride

Streptococcus pyogenes M1 GAS strain:SF370

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Elimination of chromosomal island SpyCIM1 from Streptococcus pyogenes strain SF370 reverses the mutator phenotype and alters global transcription

Project description:Streptococcus pyogenes chromosomal island M1 (SpyCIM1) integrates by site-specific recombination into the 5’ end of DNA mismatch repair (MMR) gene mutL in strain SF370SmR, blocking transcription of it and the downstream operon genes. During exponential growth, SpyCIM1 excises from the chromosome and replicates as an episome, restoring mutL transcription. This process is reversed in stationary phase with SpyCIM1 re-integrating into mutL, returning the cells to a mutator phenotype. Here we show that elimination of SpyCIM1 relieves this mutator phenotype. The downstream MMR operon genes, multidrug efflux pump lmrP, Holliday junction resolution helicase ruvA, and DNA base excision repair glycosylase tag, are also restored to constitutive expression by elimination of SpyCIM1. The presence of SpyCIM1 alters global transcription patterns in SF370SmR. RNA sequencing (RNA-Seq) demonstrated that loss of SpyCIM1 in the SpyCIM1 deletion mutant, CEM1∆4, impacted the expression of many genes both in early exponential phase, when the SpyCIM1 is episomal, as well as at the onset of stationary phase, when SpyCIM1 has reintegrated into mutL. Among these changes, the up regulation of the genes for the antiphagocytic M protein (emm1), streptolysin O (slo), capsule operon (hasABC), and streptococcal pyrogenic exotoxin (speB), are particularly notable. The expression pattern of the DNA mismatch repair (MMR) operon confirmed our earlier observations that these genes are transcribed in early exponential phase but silenced as stationary phase is approached. The direct role of SpyCIM1 in causing the mutator phenotype is confirmed by these studies, and its influence upon the biology of S. pyogenes was found to impact multiple genes in addition to the MMR operon. We suggest that such chromosomal islands are a remarkable evolutionary adaptation to promote the survival of its S. pyogenes host cell in changing environments.

2015-12-03 | GSE75633 | GEO

Microarray analysis of Rgg-dependent transcriptional regulation in Streptococcus suis serotype 2 strain 05ZYH33

Project description:Streptococcus suis 2 Rgg-dependent transcription was analyzed. Microarray analysis was performed using RNA samples isolated from Streptococcus suis 2 wild-type strain 05ZYH33 as well as RNA isolated from 05ZYH33 rgg isogenic mutant strain during postexponential phases of growth.

2010-06-20 | E-GEOD-21940 | biostudies-arrayexpress

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