Genomics

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82-kDa ChAT and SATB1 ChIP-seq after vehicle or amyloid-beta exposure


ABSTRACT: Using chromatin immunoprecipitation and next-generation sequencing (ChIP-seq), we assessed the effects of acute exposure to oligomeric amyloid-beta on 82-kDa ChAT and SATB1 genome association in human SH-SY5Y neural cells, finding that Aβ-exposure increased 82-kDa ChAT and SATB1 association with gene promoters, introns and matrix attachment regions. We found that both SATB1 and 82-kDa ChAT associate with synapse and cell stress related genes after amyloid-beta exposure.

ORGANISM(S): Homo sapiens

PROVIDER: GSE73576 | GEO | 2016/04/11

SECONDARY ACCESSION(S): PRJNA297352

REPOSITORIES: GEO

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