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Effects of Kielin/Chordin-like Protein (KCP) in Mouse Liver

ABSTRACT: Liver RNA was collected from three genotypes: WT controls, KCP knockout (KCP-KO) mutants, and KCP-Transgenic (KCP-Tg) overexpressing mice. Mice were fed either a normal diet (ND) or a high fat diet (HFD) for 4 weeks before liver RNA extraction.

ORGANISM(S): Mus musculus

PROVIDER: GSE73594 | GEO | 2016/01/01

SECONDARY ACCESSION(S): PRJNA297378

REPOSITORIES: GEO

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Effects of Kielin/Chordin-like Protein (KCP) in Mouse Liver

Project description:Liver RNA was collected from three genotypes: WT controls, KCP knockout (KCP-KO) mutants, and KCP-Transgenic (KCP-Tg) overexpressing mice. Mice were fed either a normal diet (ND) or a high fat diet (HFD) for 4 weeks before liver RNA extraction. The differential gene expression patterns were noted between all genotypes and diets.

2016-07-03 | E-GEOD-73594 | biostudies-arrayexpress

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Project description:In this study we want to compare the gene expression profile of CD44+CXCR6+ CD8+ T cells from the liver of ND and CD-HFD mice with hepatic CD44+CXCR6neg and splenic CD44+ CX3CR1neg CD8 T cells of ND and CD-HFD mice. This comparison will reveal transcriptional signatures of hepatic CD44+CXCR6+ CD8+ T cells in CD-HFD responsible for causing liver pathology in NASH.

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