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The influence of menstrual cycle and endometriosis on endometrial methylome

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE73950 | GEO | 2016/02/15

SECONDARY ACCESSION(S): PRJNA298573

REPOSITORIES: GEO

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The influence of menstrual cycle and endometriosis on endometrial methylome

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-02-15 | E-GEOD-73950 | biostudies-arrayexpress

The influence of menstrual cycle and endometriosis on endometrial methylome.

Project description:BackgroundAlterations in endometrial DNA methylation profile have been proposed as one potential mechanism initiating the development of endometriosis. However, the normal endometrial methylome is influenced by the cyclic hormonal changes, and the menstrual cycle phase-dependent epigenetic signature should be considered when studying endometrial disorders. So far, no studies have been performed to evaluate the menstrual cycle influences and endometriosis-specific endometrial methylation pattern at the same time.ResultsInfinium HumanMethylation 450K BeadChip arrays were used to explore DNA methylation profiles of endometrial tissues from various menstrual cycle phases from 31 patients with endometriosis and 24 healthy women. The DNA methylation profile of patients and controls was highly similar and only 28 differentially methylated regions (DMRs) between patients and controls were found. However, the overall magnitude of the methylation differences between patients and controls was rather small (?? ranging from -0.01 to -0.16 and from 0.01 to 0.08, respectively, for hypo- and hypermethylated CpGs). Unsupervised hierarchical clustering of the methylation data divided endometrial samples based on the menstrual cycle phase rather than diseased/non-diseased status. Further analysis revealed a number of menstrual cycle phase-specific epigenetic changes with largest changes occurring during the late-secretory and menstrual phases when substantial rearrangements of endometrial tissue take place. Comparison of cycle phase- and endometriosis-specific methylation profile changes revealed that 13 out of 28 endometriosis-specific DMRs were present in both datasets.ConclusionsThe results of our study accentuate the importance of considering normal cyclic epigenetic changes in studies investigating endometrium-related disease-specific methylation patterns.

| S-EPMC4710036 | biostudies-literature

The influence of menstrual cycle and endometriosis on endometrial methylome

Project description:The influence of menstrual cycle and endometriosis on endometrial methylome

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Transcriptome and DNA methylation analyses highlight the role of menstrual cycle phase in tumorigenesis of endometriosis-related ovarian carcinoma histotypes.

Project description:This SuperSeries is composed of the SubSeries listed below.

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Endometriosis induced menstrual cycle dependent and independent endometrial transcriptomic dysregulation

Project description:We collected the eutopic endometrial biopsy from control women and women with endometriosis at both proliferative and secretory for RNA-seq analysis. We found regardless of endometriosis or not, the menstrual stage differences proliferative vs secretory accounts for the most changes of the transcriptome of all endometrial biopsy samples. Distinct and conserved gene expression patterns were induced by endometriosis at proliferative and secretory phases. From proliferative to secretory phase, endometriosis not only ablated the gene expression changes of some menstrual cycle dependent genes but also stimulated the menstrual cycle dependent expression changes in some new genes suggesting a dyssynchronous endometrium. Furthermore, we found eight endometriosis altered DEGs in our datasets are proximally localized to the endometriosis associated SNP at both proliferative and secretory phases. More interestingly, 75 published endometrial receptivity related genes were altered by endometriosis at secretory phase.

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Endometrial methylome of patients without endometriosis

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Endometrial methylome of patients without endometriosis

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Endometrial methylome of patients with endometriosis

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Endometriosis induced menstrual cycle dependent and independent endometrial transcriptomic dysregulation

Project description:Endometriosis induced menstrual cycle dependent and independent endometrial transcriptomic dysregulation

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