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Enhancers reside in a unique epigenetic environment during early zebrafish development [ChIP-seq & ATAC-seq]

ABSTRACT: We describe that during early zebrafish development, DNA methylation has little influence on enhancer activity, and that hypo-methylation is a unique feature of primed enhancers, whereas active enhancers are generally hyper-methylated. Hypo-methylated enhancers (hypo-enhancers) are enriched close to important transcription factors (TFs) that act later in development, are specifically de-methylated before the mid blastula transition (MBT), and reside in a unique epigenetic environment. Finally, we demonstrate that hypo-enhancers are functionally active later in development and that they are physically associated with the transcriptional start site (TSS) of target-genes, irrespective of target-gene activity.

ORGANISM(S): Danio rerio

PROVIDER: GSE74231 | GEO | 2015/11/06

SECONDARY ACCESSION(S): PRJNA299600

REPOSITORIES: GEO

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Enhancers reside in a unique epigenetic environment during early zebrafish development [4C-seq]

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