Transcriptomics

Dataset Information

0

Targeting sphingosine kinase by ABC294640 induces KSHV-infected endothelial cell autophagic death


ABSTRACT: KSHV is a principal causative agent of Kaposi's Sarcoma (KS). Despite this knowledge about the close relationship between sphingolipid metablism and solid tumors development, the role of sphingolipid metablism in KSHV-related malignancies remains mostly unclear. We report that targeting sphingosine kinase 2 (SphK2) by a selective inhibitor, ABC294640, significantly induces KSHV+ TIVE-LTC autophagic death. By using microarray analysis, we have identified the global gene profile affected by ABC294640 within KSHV+ TIVE-LTC and several novel “druggable” candidates closely related to cancer cell survival/growth. Finally, we found that targeting TIVE-LTC by ABC294640 effectively suppressed KSHV tumorigenicity by using a KS-like nude mice model.

ORGANISM(S): Homo sapiens

PROVIDER: GSE74338 | GEO | 2016/11/01

SECONDARY ACCESSION(S): PRJNA300278

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-11-01 | GSE158936 | GEO
2021-11-01 | GSE158935 | GEO
2018-01-25 | GSE101978 | GEO
2007-01-01 | GSE6482 | GEO
2008-06-14 | E-GEOD-6482 | biostudies-arrayexpress
2024-07-08 | GSE260925 | GEO
2020-01-23 | GSE144101 | GEO
2024-04-17 | PXD048212 | Pride
2020-10-29 | GSE155030 | GEO
2020-04-16 | GSE148741 | GEO