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Effect of APE1 and its acetylation on gene expression profile of lung cancer cells

ABSTRACT: APE1 regulates a vast majority of genes by acting as a transcriptional co-activator or as a co-repressor. It is overexpressed in diverse cancer tissues and is associated with their drug resistance. It is essential for cell proliferation. APE1 is post-translationally acetylated by HAT p300 at its N-terminal Lys 6 and 7 residues. We examined APE1 and its acetylation-dependent gene expression profile of lung cancer cells which would contribute to sustained proliferation of lung cancer cells. We used microarry based gene expression profile analysis using affymetrix HG-U133-Plus 2 array. For differential expression testing, Linear Models for MicroArray (Limma) was used to fit linear models for analyzing designed experiments and the assessment of overall gene expression and contrast analysis comparing the experimental groups

ORGANISM(S): Homo sapiens

PROVIDER: GSE74572 | GEO | 2016/04/28

SECONDARY ACCESSION(S): PRJNA300854

REPOSITORIES: GEO

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