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Identification of Zfp423-dependent genes in adult inguinal white adipocytes

ABSTRACT: We derived a model that allows for doxycycline-inducible deletion of Zfp423 in mature adipocytes of adult mice (Adiponectin-rtTA; TRE-CRE; Zfp423 loxP/loxP). In these animals deletion of Zfp423 results in a spontaneous conversion of white adipocytes into beige-like adipocytes at room temperature. The goal of this expression analysis was to 1) determine the gene programs dependent on adipocyte Zfp423 in inguinal WAT, and 2) determine the similarity between the converted beige-like cells to normal beige adipose tissue that accumulates upon cold exppsure.

ORGANISM(S): Mus musculus

PROVIDER: GSE74899 | GEO | 2016/02/10

SECONDARY ACCESSION(S): PRJNA301794

REPOSITORIES: GEO

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