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MRNA, miRNA and SNP profiles of 50 HB tumors

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE75285 | GEO | 2016/10/12

SECONDARY ACCESSION(S): PRJNA303087

REPOSITORIES: GEO

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SNP profiles of 50 HB tumors

Project description:Hepatoblastoma (HB) is the most common liver cancer in children, but few pre-treatment tumors have been molecularly profiled. Consequently, there are no validated prognostic or therapeutic biomarkers for HB patients. We report on molecular analysis of 88 clinically-annotated HB tumors. This analysis pointed to three risk-stratifying molecular subtypes—low, intermediate and high risk—that are characterized by differential activation of hepatic progenitor cell markers and metabolic pathways. High-risk tumors are characterized by high NFE2L2 activity and LIN28B, HMGA2, SALL4 and AFP expression, low let-7 expression and HNF1A activity, and high coordinated expression of oncofetal proteins and stem cell markers. Tests on a 35 HB validation set supported these genes as prognostic biomarkers.

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Project description:mRNA, miRNA and SNP profiles of 50 HB tumors

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Integrated genomic analyses of adrenocortical tumors (SNP array, DNA methylation, mRNA and miRNA expression).

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Integrated genomic analyses of adrenocortical tumors (SNP array, DNA methylation, mRNA and miRNA expression).