Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Robert Freilich
PROVIDER: E-GEOD-49331 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia.
Freilich Robert W RW Woodbury Maya E ME Ikezu Tsuneya T
PloS one 20131111 11
Neuroinflammation contributes to many neurologic disorders including Alzheimer's disease, multiple sclerosis, and stroke. Microglia is brain resident myeloid cells and have emerged as a key driver of the neuroinflammatory responses. MicroRNAs (miRNAs) provide a novel layer of gene regulation and play a critical role in regulating the inflammatory response of peripheral macrophages. However, little is known about the miRNA in inflammatory activation of microglia. To elucidate the role that miRNAs ...[more]
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