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DIGIT regulates endoderm differentiation of human embryonic stem cells

ABSTRACT: Endoderm differentiation is a critical step leading to development of the gastrointestinal system. We found that DIGIT is a lncRNA that is required for endoderm differentiation. We used directional RNA sequencing (RNA-seq) to globally evaluate the effects of loss of DIGIT expression during endoderm differentiation and chromatin immunoprecipitation and sequencing (ChIP-seq) to define the sites occupied by SMAD3 during endoderm diferentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE75297 | GEO | 2016/10/04

SECONDARY ACCESSION(S): PRJNA303145

REPOSITORIES: GEO

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