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TAp73 is a master regulator of airway multiciliogenesis [sRNA-Seq]

ABSTRACT: Comparative small RNA seq analysis of WT and global p73KO Mouse Tracheal Epithelial Cell (MTECs) during the course of their differentiation (Air-Liquid Interface ALI D0, D4, D7, D14) aimed to determine the role of p73 in motile multiciliogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE75716 | GEO | 2016/05/05

SECONDARY ACCESSION(S): PRJNA305143

REPOSITORIES: GEO

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TAp73 is a master regulator of airway multiciliogenesis [RNA-Seq]

Project description:Comparative RNA seq analysis of WT and global p73KO Mouse Tracheal Epithelial Cell (MTECs) during the course of their differentiation (Air-Liquid Interface ALI D0, D4, D7, D14) aimed to determine the role of p73 in motile multiciliogenesis.

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TAp73 functions through posttranscriptional codes in brain multiciliogenesis

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TAp73 functions through posttranscriptional codes in brain multiciliogenesis

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TAp73 is a master regulator of airway multiciliogenesis

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MiR-34b regulates multiciliogenesis during organ formation in zebrafish

Project description:Multiciliated cells possess multiple motile cilia on the cell surface and are widely distributed throughout the vertebrate body to perform important physiological functions by regulating fluid movement in the intercellular space. However the molecular mechanisms underlying multiciliogenesis are not well understood. Although dysregulation of members of the miR-34 family plays a critical role in the progression of various cancers, the physiological function of miR-34b, especially in regulating multiciliogenesis, is largely unknown. Here we focus on the multiciliated cells in the zebrafish kidney to study whether and how miR-34b regulate multiciliogenesis. We performed genome-wide gene expression profiling of zebrafish kidney multiciliated cells in the absence (miR-34b morpholino) or presence of miR-34b (control morpholino). RNA samples for microarray gene expression profiling were collected at 3 days post fertilization.

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