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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of dfferentiation of human bone marrow derived hMSC with beta-glycerphosphate, ascorbicacidphosphate and dexamethasone for 21 days;evaluated time points d4, d7, d14 and d21 after induction

ABSTRACT: Differentiation of bone marrow derived hMSC with beta-glycerphosphate, ascorbicacidphosphate and dexamethasone for 21 days;evaluated time points d4, d7, d14 and d21 after induction; reference d-1 (one day before induction; preconfluent 70-80%)

ORGANISM(S): Homo sapiens

SUBMITTER: paar Christine Paar

PROVIDER: E-MARS-3 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation.

Kulterer Birgit B Friedl Gerald G Jandrositz Anita A Sanchez-Cabo Fatima F Prokesch Andreas A Paar Christine C Scheideler Marcel M Windhager Reinhard R Preisegger Karl-Heinz KH Trajanoski Zlatko Z

BMC genomics 20070312

<h4>Background</h4>Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. In this study we asked if MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if artificial cultivation conditions exert any influ ...[more]

PMID: 17352823

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